KLHL6

Across TCGA cell cohorts, KLHL6 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL6-associated genes across cancer lineages are DBX2, KRT28, and MYH7. Each is linked with KLHL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL6-to-partner and partner-to-KLHL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DBX2 grouped by KLHL6-low versus KLHL6-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL6→partner) and Y-score (partner→KLHL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DBX2 →	+0.006	+5.000	<.001	.006	3	1
LUNG_NSCLC_LUAD	KRT28 →	+0.003	+2.637	<.001	.007	3	1
LUNG_NSCLC_LUAD	MYH7 →	+0.006	+2.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	TPSD1 →	+0.042	+2.807	.008	.002	3	1
BLOOD_Lymphoma	NOBOX →	+0.005	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	RPL10L →	+0.210	+4.191	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

DBX2 by KLHL6 expression — PANCREAS

Explore this box plot interactively →