KLHL42

Across TCGA patient cohorts, KLHL42 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL42-associated genes across cancer lineages are C-Raf, 14-3-3_beta, and ERK2. Each is linked with KLHL42 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL42-to-partner and partner-to-KLHL42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by KLHL42-low versus KLHL42-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL42→partner) and Y-score (partner→KLHL42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.125	+2.087	.023	.005	3	2
UCEC	14-3-3_beta →	-0.098	-2.432	.011	.018	3	1
UCEC	ERK2 →	+0.170	+2.087	.021	.005	3	1
UCEC	Heregulin →	-0.100	-3.308	.035	.009	3	1
UCEC	JNK2 →	+0.220	+1.884	.003	.030	3	1
UCEC	MEK1 →	+0.325	+2.459	.020	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

C-Raf by KLHL42 expression — UCEC

Explore this box plot interactively →