KLHL42

Across TCGA cell cohorts, KLHL42 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,184 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLHL42-associated GO terms across cancer lineages are Nuclear export, Centrosome cycle, and Constitutive heterochromatin formation. Each is linked with KLHL42 in more than 14 cancer types. Because this analysis shows association rather than direction, both KLHL42-to-partner and partner-to-KLHL42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear export grouped by KLHL42-low versus KLHL42-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL42→partner) and Y-score (partner→KLHL42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Nuclear export →	+0.107	+0.595	.001	.005	3	15
UPPER_AERODIGESTIVE_TRACT	Centrosome cycle →	+0.107	+1.135	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Constitutive heterochromatin formation →	+0.097	+1.066	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Microtubule organizing center organization →	+0.106	+1.150	<.001	<.001	3	14
BONE	Heterochromatin formation →	+0.105	+0.972	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Regulation of microtubule-based process →	+0.085	+1.597	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,184 associations by consensus.

Nuclear export by KLHL42 expression — BONE

Explore this box plot interactively →