KLHL40

Across TCGA pan-cancer cohorts, KLHL40 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KLHL40 data layer compared with 17 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher KLHL40 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KLHL40 expression acts as an unfavorable survival marker.

KICH, PAAD, and GBM are the cancer types where KLHL40 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.035	0.904	<.001	30	view →
PAAD	OS	Median	All	0.060	0.641	<.001	24	view →
GBM	OS	Median	All	0.058	0.416	<.001	12	view →
LIHC	OS	Median	All	0.098	0.774	.001	6	view →
LUSC	DFS	Median	All	0.531	0.796	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KLHL40–KICH (DFS)

Open the KICH breakdown →