KLHL4

Across TCGA patient cohorts, KLHL4 mutation is significantly associated with the RNA expression of many other genes, with 5,274 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL4-associated genes across cancer lineages are FAHD2A, CACYBP, and FAM204A. Each is linked with KLHL4 in more than 4 cancer types. Because this analysis shows association rather than direction, both KLHL4-to-partner and partner-to-KLHL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAHD2A grouped by KLHL4-low versus KLHL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL4→partner) and Y-score (partner→KLHL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAHD2A →	+0.295	+1.635	<.001	<.001	3	5
UCEC	CACYBP →	+0.373	+1.525	.004	.008	3	5
SKCM	FAM204A →	+0.366	+1.392	.001	.003	3	4
SKCM	PPP2R2D →	+0.315	+1.768	<.001	<.001	3	4
SKCM	SAPCD2 →	+0.528	+1.567	<.001	.001	3	4
UCEC	ORC6 →	+0.621	+1.799	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,274 associations by consensus.

FAHD2A by KLHL4 expression — UCEC

Explore this box plot interactively →