KLHL4

Across TCGA patient cohorts, KLHL4 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL4-associated genes across cancer lineages are Heregulin, INPP4B, and p62 Lck ligand. Each is linked with KLHL4 in more than 3 cancer types. Because this analysis shows association rather than direction, both KLHL4-to-partner and partner-to-KLHL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by KLHL4-low versus KLHL4-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL4→partner) and Y-score (partner→KLHL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Heregulin →	-0.156	-2.321	.030	.030	3	4
COAD	INPP4B →	-0.351	-2.313	.037	.035	3	3
LUSC	p62 Lck ligand →	+0.542	+1.687	.007	.013	3	2
STAD	ER-alpha →	-0.147	-2.000	.013	.025	3	2
UCEC	JNK_pT183_Y185 →	-0.161	-1.770	<.001	<.001	3	2
STAD	p70-S6K_pT389 →	-0.167	-2.222	.018	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Heregulin by KLHL4 expression — STAD

Explore this box plot interactively →