KLHL4

Across TCGA cell cohorts, KLHL4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,073 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible KLHL4-associated GO terms across cancer lineages are Positive regulation of supramolecular fiber organization, Oncostatin-M-mediated signaling pathway, and Chaperone-mediated autophagy. Each is linked with KLHL4 in more than 8 cancer types. Because this analysis shows association rather than direction, both KLHL4-to-partner and partner-to-KLHL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of supramolecular fiber organization grouped by KLHL4-low versus KLHL4-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL4→partner) and Y-score (partner→KLHL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Positive regulation of supramolecular fiber organization →	+0.061	+1.290	<.001	.003	3	9
LUNG_NSCLC_LUAD	Oncostatin-M-mediated signaling pathway →	+0.200	+1.113	<.001	.003	3	9
PANCREAS	Chaperone-mediated autophagy →	+0.162	+1.593	<.001	.001	3	9
LIVER	Response to corticotropin-releasing hormone →	-1.281	-2.794	<.001	<.001	3	9
LIVER	Cellular response to corticotropin-releasing hormone stimulus →	-1.227	-2.794	<.001	<.001	3	9
OVARY	Dentinogenesis →	+1.247	+1.395	.002	.009	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,073 associations by consensus.

Positive regulation of supramolecular fiber organization by KLHL4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →