KLHL4

Across TCGA cell cohorts, KLHL4 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL4-associated genes across cancer lineages are TCTEX1D1, VHLL, and APOA4. Each is linked with KLHL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL4-to-partner and partner-to-KLHL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCTEX1D1 grouped by KLHL4-low versus KLHL4-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL4→partner) and Y-score (partner→KLHL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TCTEX1D1 →	+0.044	+3.836	<.001	.004	3	2
LARGE_INTESTINE	VHLL →	+0.147	+3.607	<.001	.006	3	2
BLOOD_Leukemia	APOA4 →	+0.034	+4.539	<.001	.007	3	2
LUNG_NSCLC_LUSC	OPN1LW →	+0.020	+4.643	<.001	.008	3	1
OESOPHAGUS	LUZP4 →	+0.075	+3.836	.002	.004	3	1
OESOPHAGUS	ARSF →	+0.028	+4.807	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

TCTEX1D1 by KLHL4 expression — OESOPHAGUS

Explore this box plot interactively →