KLHL4

Across TCGA cell cohorts, KLHL4 mutation is significantly associated with the mutation status of many other genes, with 1,691 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL4-associated genes across cancer lineages are KDM6A, KDM2B, and ADAMTS17. Each is linked with KLHL4 in more than 3 cancer types. Because this analysis shows association rather than direction, both KLHL4-to-partner and partner-to-KLHL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KDM6A grouped by KLHL4-low versus KLHL4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL4→partner) and Y-score (partner→KLHL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KDM6A →	+2.217	+2.635	.002	.002	1	4
LARGE_INTESTINE	KDM2B →	+1.739	+2.600	.003	.003	1	3
OVARY	ADAMTS17 →	+4.415	+4.977	.007	.007	1	3
OVARY	ANKRD50 →	+4.415	+4.977	.007	.007	1	3
OVARY	CHD3 →	+4.415	+4.977	.007	.007	1	3
OVARY	IL16 →	+4.415	+4.977	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,691 associations by consensus.

KDM6A by KLHL4 expression — LARGE_INTESTINE

Explore this box plot interactively →