KLHL38

Across TCGA patient cohorts, KLHL38 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL38-associated genes across cancer lineages are TFRC, CD49b, and 14-3-3_beta. Each is linked with KLHL38 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL38-to-partner and partner-to-KLHL38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by KLHL38-low versus KLHL38-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL38→partner) and Y-score (partner→KLHL38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.462	+1.874	.015	.049	3	2
COAD	CD49b →	+0.348	+3.008	.024	.019	3	1
UCEC	14-3-3_beta →	-0.094	-2.432	.009	.018	3	1
UCEC	eIF4E →	+0.200	+3.183	.008	.009	3	1
UCEC	ERK2 →	+0.175	+1.584	.011	.019	3	1
UCEC	Heregulin →	-0.098	-2.571	.028	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

TFRC by KLHL38 expression — UCEC

Explore this box plot interactively →