KLHL36

Across TCGA patient cohorts, KLHL36 mutation is significantly associated with the RNA expression of many other genes, with 2,077 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL36-associated genes across cancer lineages are RAD51C, C1QBP, and ANKRD39. Each is linked with KLHL36 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL36-to-partner and partner-to-KLHL36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51C grouped by KLHL36-low versus KLHL36-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL36→partner) and Y-score (partner→KLHL36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51C →	+0.326	+1.781	.005	.008	3	3
UCEC	C1QBP →	+0.565	+3.949	<.001	<.001	3	3
UCEC	ANKRD39 →	+0.293	+2.828	<.001	.001	3	3
UCEC	HSBP1L1 →	+0.417	+1.856	.001	.004	3	3
STAD	EIF5A →	+0.757	+3.203	<.001	.009	3	3
UCEC	COQ6 →	+0.195	+2.423	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,077 associations by consensus.

RAD51C by KLHL36 expression — UCEC

Explore this box plot interactively →