KLHL36

Across TCGA patient cohorts, KLHL36 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL36-associated genes across cancer lineages are eEF2, eIF4E, and FASN. Each is linked with KLHL36 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL36-to-partner and partner-to-KLHL36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by KLHL36-low versus KLHL36-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL36→partner) and Y-score (partner→KLHL36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.361	+2.115	.003	.017	3	3
UCEC	eIF4E →	+0.202	+2.070	.005	.001	3	3
COAD	FASN →	+0.443	+2.815	.039	.036	3	2
UCEC	FoxM1 →	+0.255	+2.070	.004	.001	3	2
UCEC	JNK_pT183_Y185 →	-0.152	-1.427	.009	.024	3	2
UCEC	Lck →	+0.248	+1.440	<.001	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

eEF2 by KLHL36 expression — UCEC

Explore this box plot interactively →