Across TCGA patient cohorts, KLHL34 mutation is significantly associated with the RNA expression of many other genes, with 1,973 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL34-associated genes across cancer lineages are TAF9, ZNF833P, and MIR6071. Each is linked with KLHL34 in more than 3 cancer types. Because this analysis shows association rather than direction, both KLHL34-to-partner and partner-to-KLHL34 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL34→partner) and Y-score (partner→KLHL34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TAF9 →	+0.493	+3.021	<.001	<.001	3	4
CESC	ZNF833P →	+0.039	+4.996	<.001	.002	3	3
CESC	MIR6071 →	+0.668	+4.320	<.001	.007	3	3
LUSC	DDB2 →	+0.616	+2.632	<.001	.005	3	3
UCEC	FAXDC2 →	-0.706	-3.237	<.001	<.001	3	3
COAD	OR4C46 →	+0.021	+4.282	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,973 associations by consensus.

Exploration

KLHL34 survival (RNA) · tumor vs normal (RNA) · all KLHL34 data types