Across TCGA patient cohorts, KLHL34 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL34-associated genes across cancer lineages are ATM, RAD51, and Notch1. Each is linked with KLHL34 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL34-to-partner and partner-to-KLHL34 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL34→partner) and Y-score (partner→KLHL34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.385	-1.807	.012	.004	3	3
COAD	RAD51 →	+0.121	+2.584	.026	.010	3	3
UCEC	Notch1 →	+0.122	+2.424	.010	.001	3	2
UCEC	PCNA →	+0.203	+1.700	.005	.040	3	2
UCEC	Stathmin →	+0.147	+2.026	.001	.016	3	2
COAD	4E-BP1 →	+0.202	+2.115	.007	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Exploration

KLHL34 survival (RNA) · tumor vs normal (RNA) · all KLHL34 data types