Across TCGA cell cohorts, KLHL34 mutation is significantly associated with the RNA expression of many other genes, with 245 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL34-associated genes across cancer lineages are ATP1B4, BMP15, and RD3L. Each is linked with KLHL34 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL34-to-partner and partner-to-KLHL34 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL34→partner) and Y-score (partner→KLHL34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ATP1B4 →	+0.006	+4.906	<.001	.006	3	2
OESOPHAGUS	BMP15 →	+0.030	+4.906	<.001	.006	3	1
LUNG_SCLC	RD3L →	+0.032	+5.029	<.001	.006	3	1
BLOOD_Leukemia	NUDT10 →	+1.421	+3.754	<.001	.002	3	1
BLOOD_Leukemia	ADAMTS18 →	+0.639	+3.868	<.001	.002	3	1
BLOOD_Leukemia	CPXCR1 →	+0.063	+4.234	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 245 associations by consensus.

Exploration

KLHL34 survival (RNA) · tumor vs normal (RNA) · all KLHL34 data types