Across TCGA patient cohorts, KLHL32 mutation is significantly associated with the RNA expression of many other genes, with 4,468 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL32-associated genes across cancer lineages are LINC02210-CRHR1, MIR128-1, and CHAF1A. Each is linked with KLHL32 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL32-to-partner and partner-to-KLHL32 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL32→partner) and Y-score (partner→KLHL32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC02210-CRHR1 →	+0.147	+4.409	<.001	.006	3	3
COAD	MIR128-1 →	+0.343	+3.736	.006	.001	3	3
UCEC	CHAF1A →	+0.720	+3.065	<.001	<.001	3	3
UCEC	LMNB2 →	+0.784	+2.678	<.001	<.001	3	3
UCEC	POLE →	+0.458	+1.680	<.001	<.001	3	3
UCEC	PGAM5 →	+0.662	+2.369	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,468 associations by consensus.

Exploration

KLHL32 survival (RNA) · tumor vs normal (RNA) · all KLHL32 data types