Across TCGA patient cohorts, KLHL32 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL32-associated genes across cancer lineages are Annexin_VII, Gab2, and PAI-1. Each is linked with KLHL32 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL32-to-partner and partner-to-KLHL32 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL32→partner) and Y-score (partner→KLHL32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin_VII →	-0.120	-1.716	.007	.003	3	3
UCEC	Gab2 →	+0.296	+1.716	.010	.003	3	2
UCEC	PAI-1 →	+0.231	+1.502	.038	.027	3	2
UCEC	ATM →	-0.411	-2.087	.005	.005	3	2
UCEC	4E-BP1_pT37_T46 →	-0.317	-1.222	.009	.035	3	2
COAD	Caspase-7-cleavedD198 →	+1.103	+2.824	.011	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Exploration

KLHL32 survival (RNA) · tumor vs normal (RNA) · all KLHL32 data types