Across TCGA cell cohorts, KLHL32 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible KLHL32-associated genes across cancer lineages are LUZP4, TUBA3E, and IQCF6. Each is linked with KLHL32 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL32-to-partner and partner-to-KLHL32 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL32→partner) and Y-score (partner→KLHL32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LUZP4 →	+0.085	+4.350	<.001	.005	3	2
LARGE_INTESTINE	TUBA3E →	+0.124	+3.591	<.001	.002	3	1
LARGE_INTESTINE	IQCF6 →	+0.161	+2.560	.001	.008	3	1
LARGE_INTESTINE	MTFR1 →	+0.640	+3.215	.003	.009	3	1
LARGE_INTESTINE	PSMD5 →	+0.569	+3.082	<.001	.007	3	1
BLOOD_Lymphoma	APOA5 →	+0.030	+4.523	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

KLHL32 survival (RNA) · tumor vs normal (RNA) · all KLHL32 data types