KLHL3

Across TCGA patient cohorts, KLHL3 mutation is significantly associated with the RNA expression of many other genes, with 3,321 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL3-associated genes across cancer lineages are RNU7-12P, RNA5SP86, and USP17L14P. Each is linked with KLHL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL3-to-partner and partner-to-KLHL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-12P grouped by KLHL3-low versus KLHL3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL3→partner) and Y-score (partner→KLHL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU7-12P →	+0.505	+3.855	.004	.006	3	3
COAD	RNA5SP86 →	+0.573	+4.142	<.001	.006	3	3
STAD	USP17L14P →	+0.015	+4.502	<.001	.005	3	3
UCEC	H2BC14 →	+0.427	+1.880	<.001	.004	3	2
UCEC	H2AC12 →	+0.495	+2.638	.001	.005	3	2
UCEC	SRCIN1 →	-0.543	-2.796	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,321 associations by consensus.

RNU7-12P by KLHL3 expression — LUAD

Explore this box plot interactively →