KLHL3

Across TCGA patient cohorts, KLHL3 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL3-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and FASN. Each is linked with KLHL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL3-to-partner and partner-to-KLHL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by KLHL3-low versus KLHL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL3→partner) and Y-score (partner→KLHL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.183	-1.415	.032	.043	3	2
UCEC	eIF4E →	+0.208	+3.713	.003	<.001	3	2
UCEC	FASN →	+0.276	+1.807	.039	.025	3	2
UCEC	GATA6 →	-0.109	-3.155	.049	.018	3	2
UCEC	INPP4B →	-0.257	-2.321	.019	.005	3	2
UCEC	MEK1 →	+0.453	+3.906	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

EGFR_pY1068 by KLHL3 expression — UCEC

Explore this box plot interactively →