KLHL3

Across TCGA cell cohorts, KLHL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,309 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KLHL3-associated GO terms across cancer lineages are Distal tubule morphogenesis, Negative regulation of myoblast fusion, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with KLHL3 in more than 14 cancer types. Because this analysis shows association rather than direction, both KLHL3-to-partner and partner-to-KLHL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Distal tubule morphogenesis grouped by KLHL3-low versus KLHL3-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL3→partner) and Y-score (partner→KLHL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Distal tubule morphogenesis →	-0.268	-0.664	<.001	<.001	3	15
BREAST	Negative regulation of myoblast fusion →	+0.136	+0.888	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.141	+1.248	<.001	<.001	3	14
BREAST	Regulation of syncytium formation by plasma membrane fusion →	+0.113	+0.799	<.001	<.001	3	14
BREAST	Regulation of myoblast fusion →	+0.120	+0.880	<.001	<.001	3	13
BONE	Cilium movement →	-0.100	-0.818	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,309 associations by consensus.

Distal tubule morphogenesis by KLHL3 expression — CNS

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