KLHL3

Across TCGA cell cohorts, KLHL3 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL3-associated genes across cancer lineages are IQCF6, SULT4A1, and TLX3. Each is linked with KLHL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL3-to-partner and partner-to-KLHL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF6 grouped by KLHL3-low versus KLHL3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL3→partner) and Y-score (partner→KLHL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IQCF6 →	+0.168	+2.882	.001	.005	3	2
LARGE_INTESTINE	SULT4A1 →	+1.228	+3.497	<.001	.004	3	1
LARGE_INTESTINE	TLX3 →	+0.455	+3.108	<.001	.002	3	1
LARGE_INTESTINE	ANO5 →	+0.632	+3.541	<.001	.004	3	1
LARGE_INTESTINE	OR10W1 →	+0.012	+3.240	<.001	.004	3	1
LARGE_INTESTINE	OR52A1 →	+0.007	+3.084	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

IQCF6 by KLHL3 expression — LARGE_INTESTINE

Explore this box plot interactively →