KLHL28

Across TCGA pan-cancer cohorts, KLHL28 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KLHL28 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher KLHL28 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KLHL28 expression acts as an unfavorable survival marker.

SCLC, ESCA, and SARC are the cancer types where KLHL28 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	All	0.082	0.708	<.001	36	view →
ESCA	OS	Median	II,III,IV	0.117	0.703	<.001	36	view →
SARC	DFS	Median	All	0.156	0.613	.010	6	view →
PRAD	DFS	Median	All	0.085	0.774	.007	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LIHC	DFS	Median	II,III,IV	0.044	0.427	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KLHL28–SCLC (OS)

Open the SCLC breakdown →