KLHL28

Across TCGA patient cohorts, KLHL28 mutation is significantly associated with the RNA expression of many other genes, with 2,220 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL28-associated genes across cancer lineages are LINC02559, VTRNA2-2P, and ATP6V1D. Each is linked with KLHL28 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL28-to-partner and partner-to-KLHL28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02559 grouped by KLHL28-low versus KLHL28-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL28→partner) and Y-score (partner→KLHL28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC02559 →	+1.025	+5.342	<.001	.002	3	2
CESC	VTRNA2-2P →	+0.392	+4.601	<.001	.004	3	2
UCEC	ATP6V1D →	+0.447	+2.146	<.001	<.001	3	2
UCEC	ATG4A →	+0.372	+1.485	<.001	.003	3	2
COAD	MTND3P13 →	+0.255	+5.893	<.001	.002	3	2
UCEC	TRAPPC4 →	+0.315	+2.202	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,220 associations by consensus.

LINC02559 by KLHL28 expression — CESC

Explore this box plot interactively →