KLHL28

Across TCGA patient cohorts, KLHL28 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL28-associated genes across cancer lineages are Caspase-7-cleavedD198, JNK2, and ATM. Each is linked with KLHL28 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL28-to-partner and partner-to-KLHL28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by KLHL28-low versus KLHL28-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL28→partner) and Y-score (partner→KLHL28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.548	+2.341	.002	<.001	3	3
UCEC	JNK2 →	+0.162	+1.424	.008	.027	3	2
UCEC	ATM →	-0.515	-2.485	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.076	-2.973	.014	<.001	3	1
UCEC	EGFR_pY1068 →	-0.213	-1.415	.006	.010	3	1
UCEC	eIF4E →	+0.154	+1.847	.018	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Caspase-7-cleavedD198 by KLHL28 expression — UCEC

Explore this box plot interactively →