KLHL28

Across TCGA cell cohorts, KLHL28 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL28-associated genes across cancer lineages are OR4K1, OR10T2, and OR6C65. Each is linked with KLHL28 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL28-to-partner and partner-to-KLHL28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4K1 grouped by KLHL28-low versus KLHL28-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL28→partner) and Y-score (partner→KLHL28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR4K1 →	+0.027	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR10T2 →	+0.033	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR6C65 →	+0.027	+5.022	<.001	.002	3	1
LARGE_INTESTINE	RBMY1E →	+0.055	+5.022	<.001	.002	3	1
LARGE_INTESTINE	CCL23 →	+0.387	+4.930	<.001	.001	3	1
LARGE_INTESTINE	OR1S1 →	+0.035	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR4K1 by KLHL28 expression — LARGE_INTESTINE

Explore this box plot interactively →