Across TCGA pan-cancer cohorts, KLHL23 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KLHL23 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher KLHL23 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KLHL23 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, UCEC, and PRAD are the cancer types where KLHL23 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.387	0.811	<.001	21	view →
UCEC	DFS	Median	II,III,IV	1.000	0.442	.027	8	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: KLHL23 tumor-vs-normal RNA expression · all KLHL23 data types