Across TCGA patient cohorts, KLHL23 RNA expression is significantly associated with the protein abundance of many other proteins, with 26,256 significant associations in total. GBM shows the largest number of these associations.

The most reproducible KLHL23-associated proteins across cancer lineages are ILKAP, PNN, and RIF1. Each is linked with KLHL23 in more than 7 cancer types. Because this analysis shows association rather than direction, both KLHL23-to-partner and partner-to-KLHL23 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL23→partner) and Y-score (partner→KLHL23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ILKAP →	+0.397	+0.892	<.001	<.001	3	8
GBM	PNN →	+0.335	+0.894	.001	<.001	3	7
GBM	RIF1 →	+0.449	+1.010	<.001	<.001	3	7
LSCC	WRNIP1 →	+0.395	+0.905	<.001	<.001	3	7
HNSC	EHMT2 →	+0.261	+1.078	<.001	<.001	3	7
BRCA	MDC1 →	+0.531	+0.740	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 26,256 associations by consensus.

Exploration

KLHL23 survival (RNA) · tumor vs normal (RNA) · all KLHL23 data types