Across TCGA patient cohorts, KLHL23 mutation is significantly associated with the RNA expression of many other genes, with 2,026 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL23-associated genes across cancer lineages are LINC02022, FXNP1, and OR6K5P. Each is linked with KLHL23 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL23-to-partner and partner-to-KLHL23 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL23→partner) and Y-score (partner→KLHL23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	LINC02022 →	+0.521	+3.173	.003	.006	3	3
SKCM	FXNP1 →	+0.074	+5.219	<.001	.002	3	3
READ	OR6K5P →	+0.027	+4.257	.003	.007	3	2
READ	LINC01639 →	+0.387	+3.877	<.001	.003	3	2
LUSC	RFKP2 →	+0.098	+5.706	.004	.003	3	2
LUAD	SEPTIN7P4 →	+0.132	+4.712	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,026 associations by consensus.

Exploration

KLHL23 survival (RNA) · tumor vs normal (RNA) · all KLHL23 data types