KLHL22

Across TCGA pan-cancer cohorts, KLHL22 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KLHL22 data layer compared with 20 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KLHL22 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated KLHL22 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LIHC, and ACC are the cancer types where KLHL22 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	1.000	0.865	.026	10	view →
LIHC	OS	Median	All	0.164	0.704	.025	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

KLHL22–UCEC (OS)

Open the UCEC breakdown →