KLHL22

Across TCGA pan-cancer cohorts, KLHL22 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KLHL22 data layer compared with 20 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher KLHL22 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KLHL22 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where KLHL22 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.917	0.616	<.001	40	view →
LSCC	DFS	Median	All	0.560	0.991	.016	5	view →
LUAD	OS	Median	III,IV	1.000	0.789	.016	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

KLHL22–CCRCC (OS)

Open the CCRCC breakdown →