KLHL21

Across TCGA patient cohorts, KLHL21 protein abundance is significantly associated with the RNA expression of many other genes, with 935 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible KLHL21-associated genes across cancer lineages are NOS3, ZNF385D-AS1, and SUGT1P1. Each is linked with KLHL21 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL21-to-partner and partner-to-KLHL21 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLHL21 versus NOS3 in HNSC, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL21→partner) and Y-score (partner→KLHL21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NOS3 →	+0.852	+0.721	.004	<.001	3	2
HNSC	ZNF385D-AS1 →	+0.975	+0.859	.009	.008	3	2
HNSC	SUGT1P1 →	+1.248	+0.628	.003	.002	3	2
LSCC	RPL31P44 →	+0.761	+0.541	.004	.002	3	2
PDAC	MYL6 →	+0.797	+1.132	.001	.001	3	2
UCEC	SPEG →	+0.765	+0.600	.009	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 935 associations by consensus.

KLHL21 vs NOS3 — HNSC

Explore this scatter interactively →