KLHL21

Across TCGA patient cohorts, KLHL21 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL21-associated genes across cancer lineages are JNK_pT183_Y185, PDK1_pS241, and VHL. Each is linked with KLHL21 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL21-to-partner and partner-to-KLHL21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by KLHL21-low versus KLHL21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL21→partner) and Y-score (partner→KLHL21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.178	-2.446	.028	.020	3	1
UCEC	PDK1_pS241 →	+0.207	+3.026	.012	.018	3	1
UCEC	VHL →	-0.789	-3.000	.016	.036	3	1
UCEC	Di-Ras3 →	-0.154	-2.459	.031	.020	3	1
UCEC	Shc_pY317 →	-0.153	-2.459	.037	.020	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

JNK_pT183_Y185 by KLHL21 expression — UCEC

Explore this box plot interactively →