KLHL21

Across TCGA cell cohorts, KLHL21 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,670 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL21-associated GO terms across cancer lineages are Response to oscillatory fluid shear stress, Cellular response to oscillatory fluid shear stress, and Vascular endothelial cell response to oscillatory fluid shear stress. Each is linked with KLHL21 in more than 10 cancer types. Because this analysis shows association rather than direction, both KLHL21-to-partner and partner-to-KLHL21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to oscillatory fluid shear stress grouped by KLHL21-low versus KLHL21-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL21→partner) and Y-score (partner→KLHL21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Response to oscillatory fluid shear stress →	+0.163	+0.984	<.001	<.001	3	11
BREAST	Cellular response to oscillatory fluid shear stress →	+0.163	+0.984	<.001	<.001	3	11
BREAST	Vascular endothelial cell response to oscillatory fluid shear stress →	+0.163	+0.984	<.001	<.001	3	11
LIVER	Positive regulation of intracellular transport →	+0.071	+0.834	.001	.003	3	10
BREAST	Positive regulation of cell growth →	+0.064	+0.793	<.001	<.001	3	10
LARGE_INTESTINE	Canonical glycolysis →	+0.080	+0.651	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,670 associations by consensus.

Response to oscillatory fluid shear stress by KLHL21 expression — BREAST

Explore this box plot interactively →