KLHL21

Across TCGA cell cohorts, KLHL21 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL21-associated genes across cancer lineages are LRRC10, OR1L3, and DYTN. Each is linked with KLHL21 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL21-to-partner and partner-to-KLHL21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC10 grouped by KLHL21-low versus KLHL21-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL21→partner) and Y-score (partner→KLHL21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LRRC10 →	+0.018	+3.688	<.001	.002	3	2
SKIN	OR1L3 →	+0.022	+4.415	<.001	.007	3	1
SKIN	DYTN →	+0.107	+5.217	<.001	<.001	3	1
BLOOD_Leukemia	ADAM30 →	+0.013	+4.984	<.001	.002	3	1
BLOOD_Leukemia	VWC2 →	+0.307	+3.551	.008	.009	3	1
BLOOD_Leukemia	SLC6A17 →	+0.205	+4.037	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

LRRC10 by KLHL21 expression — LARGE_INTESTINE

Explore this box plot interactively →