KLHL2

Across TCGA pan-cancer cohorts, KLHL2 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KLHL2 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher KLHL2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KLHL2 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LUAD, LSCC, and CCRCC are the cancer types where KLHL2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.853	0.923	.044	3	view →
LSCC	OS	Quartile	All	0.855	0.508	.040	2	view →
CCRCC	DFS	Median	II,III,IV	0.221	1.000	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

KLHL2–LUAD (DFS)

Open the LUAD breakdown →