KLHL2

Across TCGA patient cohorts, KLHL2 protein abundance is significantly associated with the RNA expression of many other genes, with 4,694 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KLHL2-associated genes across cancer lineages are UTP4, PI4KB, and RBM34. Each is linked with KLHL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL2-to-partner and partner-to-KLHL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLHL2 versus UTP4 in CCRCC, with a Pearson correlation of -0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL2→partner) and Y-score (partner→KLHL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	UTP4 →	-0.680	-0.540	.002	.003	3	2
BRCA	PI4KB →	-0.760	-0.570	.002	<.001	3	2
CCRCC	RBM34 →	-0.252	-0.577	<.001	.001	3	2
CCRCC	MYCBP →	-0.546	-0.535	<.001	.003	3	2
CCRCC	PMS2P1 →	-0.469	-0.494	.003	.008	3	2
BRCA	NELFCD →	-0.808	-0.478	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,694 associations by consensus.

KLHL2 vs UTP4 — CCRCC

Explore this scatter interactively →