KLHL2

Across TCGA patient cohorts, KLHL2 protein abundance is significantly associated with the protein abundance of many other proteins, with 10,949 significant associations in total. GBM shows the largest number of these associations.

The most reproducible KLHL2-associated proteins across cancer lineages are ZC3H13_S110, ALG3_S13, and ITCH_S240. Each is linked with KLHL2 in more than 3 cancer types. Because this analysis shows association rather than direction, both KLHL2-to-partner and partner-to-KLHL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLHL2 versus ZC3H13_S110 in BRCA, with a Pearson correlation of -0.38.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL2→partner) and Y-score (partner→KLHL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZC3H13_S110 →	-0.848	-0.594	.006	<.001	2	4
BRCA	ALG3_S13 →	-1.274	-0.555	.002	.001	3	2
LUAD	ITCH_S240 →	-1.001	-0.507	.006	<.001	3	2
GBM	RSF1_S1282 →	-1.024	-0.444	<.001	<.001	3	2
GBM	SF3B1 →	-0.254	-0.322	.001	.003	3	2
GBM	SIN3B_S740 →	-0.510	-0.327	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,949 associations by consensus.

KLHL2 vs ZC3H13_S110 — BRCA

Explore this scatter interactively →