KLHL2

Across TCGA cell cohorts, KLHL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,191 significant associations in total. BONE shows the largest number of these associations.

The most reproducible KLHL2-associated GO terms across cancer lineages are Regulation of SREBP signaling pathway, Positive regulation of post-translational protein modification, and Positive regulation of SREBP signaling pathway. Each is linked with KLHL2 in more than 10 cancer types. Because this analysis shows association rather than direction, both KLHL2-to-partner and partner-to-KLHL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of SREBP signaling pathway grouped by KLHL2-low versus KLHL2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL2→partner) and Y-score (partner→KLHL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of SREBP signaling pathway →	+0.104	+0.891	<.001	<.001	3	11
BLOOD_Lymphoma	Positive regulation of post-translational protein modification →	+0.040	+1.007	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Positive regulation of SREBP signaling pathway →	+0.092	+0.726	.005	.005	2	11
BONE	Positive regulation of protein binding →	+0.168	+0.987	<.001	<.001	3	9
BLOOD_Lymphoma	Positive regulation of protein modification by small protein conjugation or removal →	+0.041	+1.115	<.001	<.001	3	9
STOMACH	Regulation of protein modification by small protein conjugation or removal →	+0.044	+0.648	.006	.003	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,191 associations by consensus.

Regulation of SREBP signaling pathway by KLHL2 expression — STOMACH

Explore this box plot interactively →