KLHL2

Across TCGA cell cohorts, KLHL2 mutation is significantly associated with the drug of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL2-associated genes across cancer lineages are Niraparib, GSK3337463A, and 123138. Each is linked with KLHL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL2-to-partner and partner-to-KLHL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Niraparib grouped by KLHL2-low versus KLHL2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL2→partner) and Y-score (partner→KLHL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Niraparib →	+0.471	+2.700	.004	.030	3	1
LARGE_INTESTINE	GSK3337463A →	+0.328	+2.710	.043	.027	3	1
LARGE_INTESTINE	123138 →	+0.304	+2.871	.030	.021	3	1
LARGE_INTESTINE	Masitinib →	+0.458	+2.652	.033	.045	3	1
LARGE_INTESTINE	TPCA-1 →	+0.540	+2.786	.023	.037	3	1
LARGE_INTESTINE	ETP-45835 →	+0.266	+2.652	.027	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Niraparib by KLHL2 expression — LARGE_INTESTINE

Explore this box plot interactively →