KLHL18

Across TCGA pan-cancer cohorts, KLHL18 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KLHL18 data layer compared with 21 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KLHL18 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated KLHL18 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where KLHL18 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	III,IV	1.000	0.746	.007	33	view →
CCRCC	OS	Median	II,III,IV	0.927	0.497	.016	6	view →
LSCC	OS	Tertile	II,III,IV	0.942	0.554	.005	5	view →
LUAD	DFS	Quartile	All	0.811	0.500	.046	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KLHL18–HNSC (OS)

Open the HNSC breakdown →