Across TCGA patient cohorts, KLHL17 mutation is significantly associated with the RNA expression of many other genes, with 2,697 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL17-associated genes across cancer lineages are SEMG2, IGHD5-24, and EXOG. Each is linked with KLHL17 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL17-to-partner and partner-to-KLHL17 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL17→partner) and Y-score (partner→KLHL17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SEMG2 →	+0.591	+3.742	.007	.006	3	3
CESC	IGHD5-24 →	+1.345	+4.669	<.001	.007	3	2
UCEC	EXOG →	+0.443	+2.662	<.001	<.001	3	2
UCEC	FBXO33 →	+0.460	+3.491	.001	.002	3	2
UCEC	DPY19L1 →	+0.680	+2.831	<.001	.001	3	2
COAD	TRAJ30 →	+0.991	+3.496	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,697 associations by consensus.

Exploration

KLHL17 survival (RNA) · tumor vs normal (RNA) · all KLHL17 data types