Across TCGA patient cohorts, KLHL17 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL17-associated genes across cancer lineages are Notch1, Fibronectin, and FoxM1. Each is linked with KLHL17 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL17-to-partner and partner-to-KLHL17 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL17→partner) and Y-score (partner→KLHL17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.155	+2.222	.009	.011	3	2
UCEC	Fibronectin →	-0.312	-3.160	.026	.019	3	1
UCEC	FoxM1 →	+0.234	+2.331	.033	.019	3	1
UCEC	mTOR_pS2448 →	-0.135	-3.150	.033	.019	3	1
UCEC	PCNA →	+0.340	+2.906	<.001	.001	3	1
UCEC	RAD51 →	+0.154	+1.700	.009	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

KLHL17 survival (RNA) · tumor vs normal (RNA) · all KLHL17 data types