KLHL15

Across TCGA cell cohorts, KLHL15 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,029 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL15-associated GO terms across cancer lineages are DNA biosynthetic process, Heterochromatin organization, and Dosage compensation by inactivation of X chromosome. Each is linked with KLHL15 in more than 14 cancer types. Because this analysis shows association rather than direction, both KLHL15-to-partner and partner-to-KLHL15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA biosynthetic process grouped by KLHL15-low versus KLHL15-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL15→partner) and Y-score (partner→KLHL15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DNA biosynthetic process →	+0.067	+0.674	.001	.004	3	15
STOMACH	Heterochromatin organization →	+0.097	+1.060	<.001	.001	3	15
BLOOD_Lymphoma	Dosage compensation by inactivation of X chromosome →	+0.112	+1.160	<.001	<.001	3	14
OESOPHAGUS	Peptidyl-serine autophosphorylation →	+0.147	+0.967	.001	.002	3	14
STOMACH	Heterochromatin formation →	+0.102	+0.943	<.001	<.001	3	14
BREAST	Regulation of cytokinesis →	+0.095	+0.973	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,029 associations by consensus.

DNA biosynthetic process by KLHL15 expression — PANCREAS

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