KLHL15

Across TCGA cell cohorts, KLHL15 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL15-associated genes across cancer lineages are MYF5, MYOD1, and MC2R. Each is linked with KLHL15 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL15-to-partner and partner-to-KLHL15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYF5 grouped by KLHL15-low versus KLHL15-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL15→partner) and Y-score (partner→KLHL15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYF5 →	+0.013	+5.201	<.001	.006	3	1
BLOOD_Leukemia	MYOD1 →	+0.015	+4.922	.001	.009	3	1
BLOOD_Leukemia	MC2R →	+0.006	+5.969	<.001	.001	3	1
LARGE_INTESTINE	SPIC →	+0.304	+4.095	<.001	.009	3	1
LARGE_INTESTINE	OR2V2 →	+0.028	+4.095	<.001	.009	3	1
LARGE_INTESTINE	BTNL2 →	+0.081	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MYF5 by KLHL15 expression — BLOOD_Leukemia

Explore this box plot interactively →