Across TCGA patient cohorts, KLHL14 mutation is significantly associated with the RNA expression of many other genes, with 2,562 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL14-associated genes across cancer lineages are ZWINT, MED31, and RNF25. Each is linked with KLHL14 in more than 4 cancer types. Because this analysis shows association rather than direction, both KLHL14-to-partner and partner-to-KLHL14 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL14→partner) and Y-score (partner→KLHL14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ZWINT →	+0.532	+2.241	.001	.005	3	5
UCEC	MED31 →	+0.363	+2.928	.004	<.001	3	4
UCEC	RNF25 →	+0.281	+2.392	.004	<.001	3	4
SKCM	EIF4EBP1 →	+0.616	+1.682	.001	.007	3	4
SKCM	MAST1 →	+0.783	+1.682	<.001	.007	3	3
UCEC	MRPS11 →	+0.412	+2.478	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,562 associations by consensus.

Exploration

KLHL14 survival (RNA) · tumor vs normal (RNA) · all KLHL14 data types