Across TCGA patient cohorts, KLHL14 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL14-associated genes across cancer lineages are Cyclin-B1, 4E-BP1, and 14-3-3_beta. Each is linked with KLHL14 in more than 3 cancer types. Because this analysis shows association rather than direction, both KLHL14-to-partner and partner-to-KLHL14 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL14→partner) and Y-score (partner→KLHL14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.653	+2.584	.002	.001	3	3
UCEC	4E-BP1 →	+0.366	+3.199	<.001	.009	2	4
UCEC	14-3-3_beta →	-0.092	-3.143	.016	.018	3	2
UCEC	EGFR_pY1068 →	-0.253	-1.678	.008	.023	3	2
UCEC	ERK2 →	+0.162	+2.459	.028	.018	3	2
UCEC	PCNA →	+0.167	+2.087	.044	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

KLHL14 survival (RNA) · tumor vs normal (RNA) · all KLHL14 data types