Across TCGA cell cohorts, KLHL14 mutation is significantly associated with the mutation status of many other genes, with 2,262 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL14-associated genes across cancer lineages are KIAA1549L, SEMA3D, and PLEKHA7. Each is linked with KLHL14 in more than 4 cancer types. Because this analysis shows association rather than direction, both KLHL14-to-partner and partner-to-KLHL14 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL14→partner) and Y-score (partner→KLHL14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KIAA1549L →	+2.396	+3.342	.006	.006	1	5
BLOOD_Leukemia	SEMA3D →	+4.560	+5.845	<.001	<.001	1	4
BLOOD_Leukemia	PLEKHA7 →	+3.560	+5.209	<.001	<.001	1	4
BLOOD_Leukemia	CTNND2 →	+3.390	+5.080	<.001	<.001	1	4
LUNG_SCLC	ITGAM →	+3.400	+4.784	<.001	<.001	1	4
BLOOD_Leukemia	ARPP21 →	+3.560	+4.247	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,262 associations by consensus.

Exploration

KLHL14 survival (RNA) · tumor vs normal (RNA) · all KLHL14 data types