Across TCGA cell cohorts, KLHL14 mutation is significantly associated with the drug of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLHL14-associated genes across cancer lineages are MG-132, GSK429286A, and WYE-125132. Each is linked with KLHL14 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL14-to-partner and partner-to-KLHL14 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL14→partner) and Y-score (partner→KLHL14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MG-132 →	+0.207	+2.646	.047	.047	2	1
LARGE_INTESTINE	GSK429286A →	+0.315	+2.652	.044	.045	2	1
LARGE_INTESTINE	WYE-125132 →	+0.555	+2.652	.029	.045	1	1
LARGE_INTESTINE	Torin 2 →	+0.625	+2.655	.019	.044	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

KLHL14 survival (RNA) · tumor vs normal (RNA) · all KLHL14 data types