KLHL13

Across TCGA pan-cancer cohorts, KLHL13 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated KLHL13 data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KLHL13 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated KLHL13 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, READ, and TGCT are the cancer types where KLHL13 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	0.933	0.512	.008	18	view →
READ	OS	Median	All	0.223	0.842	<.001	13	view →
TGCT	DFS	Median	All	0.170	0.807	<.001	12	view →
LUAD	DFS	Median	All	0.238	0.658	.020	12	view →
LUSC	DFS	Median	All	0.139	0.707	.022	9	view →
KIRC	OS	Median	All	0.181	0.655	.046	6	view →
SARC	DFS	Median	All	0.159	0.613	.015	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

KLHL13–UCEC (DFS)

Open the UCEC breakdown →